Calcium antagonists: Do they equally protect against kidney injury?
نویسندگان
چکیده
Calcium antagonists are a heterogeneous group of drugs that affect not only different channels but different parts of the same channel. These differences translate into different renal hemodynamic effects. This Commentary discusses the implications of these differences for surrogate markers of outcome.
منابع مشابه
Calcium antagonists: effects on cardio-renal risk in hypertensive patients.
Calcium antagonists comprise 2 main subclasses, dihydropyridines and nondihydropyridines, and have been studied extensively in hypertensive patients. Early meta-analyses suggested that short-acting calcium antagonists were associated with higher mortality rates resulting from cardiovascular events and other etiologies. Recent meta-analyses failed to show any substantive difference between long ...
متن کاملA reply.
We read with interest the editorial by Staessen et al., which discusses very objectively the position of calcium antagonists in the treatment of hypertension. As scientists who are familiar with calcium antagonists both in daily practice and pre-clinical experiments, we have had difficulty in accepting negative clinical trial results on the use of calcium antagonists in hypertension. We use cal...
متن کاملCalcium antagonists and renal hemodynamics: implications for renal protection.
Recently, attention has focussed on the effects of calcium antagonists on renal function. When administered in vitro to the isolated perfused kidney, calcium antagonists exhibit consistent actions permitting characterization of their renal hemodynamic effects. Calcium antagonists do not affect the vascular tone of the vasodilated isolated perfused kidney, but they do dramatically reverse the re...
متن کاملAn antioxidant role for calcium antagonists in the prevention of adrenaline mediated myocardial and endothelial damage.
OBJECTIVE To investigate the mechanism of calcium antagonist mediated cytoprotection against the damaging effects of adrenaline in vivo on cardiac myocytes and human endothelial cells from the umbilical vein. METHODS Human endothelial cells cultured from the umbilical vein and isolated rat cardiac myocytes were treated with plasma from rats given adrenaline 30 minutes previously with pretreat...
متن کاملThe role of calcium antagonists in chronic kidney disease.
PURPOSE OF REVIEW To review goals of antihypertensive treatment in chronic kidney disease in the context of what role calcium antagonists play toward reducing progression of kidney disease. RECENT FINDINGS All recently published guidelines recommend a blood pressure goal of less than 130/80 mmHg in patients with chronic kidney disease. Use of calcium antagonists is not recommended as part of ...
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عنوان ژورنال:
- Kidney international
دوره 73 7 شماره
صفحات -
تاریخ انتشار 2008